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Since reversible inhibitors compete with high levels of ATP, it was considered that such irreversible inhibition would give a longer lived and more complete enzyme shutdown, which might translate to a lesser dependence on pharmacokinetics and thus less frequent dosing.
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Vitamin D supplementation will, at a minimum, reduce bone fracture rates, probably colorectal cancer incidence, and possibly other cancers. It is highly considered preoperatively, especially in Charcot foot and ankle reconstruction or during significant deformity correction and when the local bone is of high enough quality to be applied directly to the fusion or repair sites.